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Systematic (IUPAC) name
CAS number 77-26-9
ATC code  ?
PubChem 2481
DrugBank APRD00266
Chemical data
Formula C11H16N2O3 
Mol. mass 224.256
Pharmacokinetic data
Bioavailability well absorbed
Metabolism hepatic
Half life 35 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

Schedule III(US)

Routes oral

Butalbital, 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Butalbital is often combined with other medications, such as acetaminophen or aspirin, and is commonly prescribed for the treatment of pain and headache. The various formulations combined with codeine are FDA approved for the treatment of tension headaches.

Combinations include:

  • butalbital and acetaminophen (trade names: Axocet, Bucet, Bupap, Cephadyn, Dolgic, Phrenilin, Phrenilin Forte, Sedapap)
  • butalbital, acetaminophen, and caffeine (trade names: Fioricet, Esgic, Esgic-Plus)
  • butalbital and aspirin (trade name: Axotal)
  • butalbital, aspirin, and caffeine (trade names Fiorinal, Fiormor, Fiortal, Fortabs, Laniroif)
  • butalbital, acetaminophen, caffeine, and codeine phosphate (Fioricet #3 with Codeine)
  • butalbital, aspirin, caffeine, and codeine phosphate (trade name: Fiorinal #3 with Codeine)


Side effects

Side effects for any drug are difficult to predict, but commonly reported side effects for butalbital include:

  • Dizziness
  • Drowsiness
  • Intoxicated feeling
  • Light-headedness
  • Nausea
  • Sedation
  • Addiction
  • Severe impairment of judgement

There are other potential side effects; this list should not be considered all-inclusive.

Dangers and Risks

Butalbital is a physically and psychologically addictive barbiturate. Butalbital should not be mixed with alcohol due to increased risk of intoxication.

There are other potential risks; this list should not be considered all-inclusive.

Butalbital and Acetaminophen (Systemic). MedicinePlus Drug Information. Retrieved on December 31, 2006.

Controlled Substances in Schedule III. Drug Enforcement Administration (2007). Retrieved on 2007-01-13.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Butalbital". A list of authors is available in Wikipedia.
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