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Systematic (IUPAC) name
2-dimethylaminoethyl 2-(4-chlorophenoxy)acetate
CAS number 51-68-3
ATC code  ?
PubChem 4039
Chemical data
Formula C12H16ClNO3 
Mol. mass 257.713
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Centrophenoxine (also called Meclofenoxate, and formerly sold under the brand name Lucidril®) is a drug used to treat the symptoms of senile dementia and Alzheimer's Disease. It is a compound of two biochemicals: dimethylaminoethanol (DMAE) and parachlorophenoxyacetate (pCPA). DMAE is a natural substance, found especially in fish, and also produced in the human brain. pCPA is a synthetic compound that resembles to a variety of plant hormones called auxins.

Like DMAE, it is a precursor to the neurotransmitter acetylcholine and may increase levels of this chemical in the CNS. It is reported to improve memory and general cognition.

It is also used off-label as a nootropic, often combined with a racetam drug such as piracetam. A typical nootropic dose is 250–500mg, 1–3 times per day.

Side Effects & Contraindications

Possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid Centrophenoxine. [1] Large doses may cause tight jaw clenching.


1. Centrophenoxine Page @ The American Academy of Anti-Aging Medicine

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Centrophenoxine". A list of authors is available in Wikipedia.
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