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Vinpocetine



Vinpocetine
Systematic (IUPAC) name
(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Identifiers
CAS number 42971-09-5
ATC code N06BX18
PubChem 5673
Chemical data
Formula C22H26N2O2 
Mol. mass 350.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2.54 +/- 0.48 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

OTC

Routes  ?

Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a semisynthetic derivative of vincamine, which is extracted from the periwinkle plant. It increases cerebral blood flow and is said to improve memory.[citation needed]

It is an inhibitor of phosphodiesterases I and IV, with an IC50 of approximately 10-5 M.

The substance is widely sold as a supplement; however, there appears to be some controversy over the possibility of adverse reaction, and low initial dose is recommended by some retailers. Vinpocetine is included in many performance-enhancing supplements to help with delivery of nutrients to muscles after workout[citation needed]. There is one isolated claim of agranulocytosis[citation needed].

Additional recommended knowledge

Contents

Health and physiological applications of vinpocetine

Possible Nootropic Properties

It has been claimed in some quarters that vinpocetine has applications to improving memory, and, possibly, improving other forms of cognitive function[citation needed]. Whether this has been confirmed scientifically and objectively is yet to be established[citation needed].

Applications to muscle performance

Judging from the above, vinpocetine is regarded as having scientifically-verified applications to improving muscle performance/efficiency[citation needed]. The method via which this occurs is yet to be elaborated[citation needed].

Side-effects

Overall, Vinpocetine side-effects reported in the literature are rare, usually minor, frequently disappear with prolonged use, and rarely require discontinuance of the drug.

Stomach/ GI upset; dry mouth, rapid heart beat, low blood pressure, and rash/ hives are the main (rarely-occurring) reported side-effects. There have been no real adverse effects to this drug during human trials.

Vinpocetine is not recommended for pregnant women (at doses higher than 2-5 mg).

Care should be taken when it is taken with other nootropics. It is always recommended that a physician be consulted before use.

Dosage

It is recommended that first-time users ingest only 2-5 mg of vinpocetine to make sure they are not hypersensitive to it. Users may then increase the dosage to 10-30 mg a day (which may, although very rarely, cause some side-effects).

  • Vinpocetine for cognitive impairment and dementia - Cochrane review

References


     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Vinpocetine". A list of authors is available in Wikipedia.
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