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Propentofylline



Propentofylline
Systematic (IUPAC) name
3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
Identifiers
CAS number 55242-55-2
ATC code N06BC02
PubChem 4938
Chemical data
Formula C15H22N4O3 
Mol. mass 306.360 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Propentofylline is a xanthine derivative and phosphodiesterase inhibitor with purported neuroprotective effects. It is being studied as a possible treatment for Alzheimer's disease and multi-infarct dementia.[1][2]

Additional recommended knowledge

Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.[3][4]

See also

References

  1. ^ Frampton M, Harvey RJ, Kirchner V (2003). "Propentofylline for dementia". Cochrane database of systematic reviews (Online) (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440.
  2. ^ Kittner B, Rössner M, Rother M (1997). "Clinical trials in dementia with propentofylline". Ann. N. Y. Acad. Sci. 826: 307–16. PMID 9329701.
  3. ^ Bath PM, Bath-Hextall FJ (2004). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". Cochrane database of systematic reviews (Online) (3): CD000162. doi:10.1002/14651858.CD000162.pub2. PMID 15266424.
  4. ^ Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". J. Cereb. Blood Flow Metab. 13 (3): 526–30. PMID 8478410.



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Propentofylline". A list of authors is available in Wikipedia.
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