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Aniracetam



Aniracetam
IUPAC name 1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Identifiers
CAS number 72432-10-1
PubChem 2196
SMILES COC1=CC=C(C=C1)C(=O)N2CCCC2=O
Properties
Molecular formula C12H13NO3
Molar mass 219.237
Pharmacology
Bioavailability ~100%
Routes of
administration
Oral and parenteral
Elimination
half-life
4 - 5 hr
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Aniracetam (Draganon®, Sarpul®, Ampamet®) is a nootropic drug of the racetam family purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects, but has not been tested in healthy, unimpaired humans. It has shown potential as an anxiolytic in three clinical animal models.

Additional recommended knowledge

Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, receptor antagonists haloperidol, mecamylamine, and ketanserin were applied. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3 dopamine, nicotinic acetylcholine, and 5-HT2A receptors[1].

See also

References

  1. ^ Nakamura K; Kurasawa M (May 2001). "Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.". Eur J Pharmacol. (Kanagawa, Japan). 420 (1): 33-43. PMID 11412837.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aniracetam". A list of authors is available in Wikipedia.
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