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Fenproporex



Fenproporex
Systematic (IUPAC) name
3-(1-phenylpropan-2-ylamino)propanenitrile
Identifiers
CAS number 16397-28-7
ATC code  ?
PubChem 61810
Chemical data
Formula C12H16N2 
Mol. mass 188.269
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Fenproporex (Perphoxene) is a stimulant drug which is used as an appetite suppressant. It is an amphetamine derivative which was developed in the 1960s and used for the treatment of obesity.[1]

Additional recommended knowledge

Fenproporex produces amphetamine as a metabolite,[2][3] and was withdrawn in many countries following problems with abuse,[4] but it is still prescribed in some countries mainly in South America.



References

  1. ^ Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de medecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
  2. ^ Tognoni G, Morselli PL, Garattini S. Amphetamine concentrations in rat brain and human urine after fenproporex administration. European Journal of Pharmacology. 1972 Oct;20(1):125-6.
  3. ^ Cody JT. Metabolic precursors to amphetamine and methamphetamine. Forensic Science Reviews 1993; 5:109.
  4. ^ Pelissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Leonetti G. Abusive prescription of psychostimulants: a study of two cases. Journal of Forensic Science. 2006 Mar;51(2):407-10.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fenproporex". A list of authors is available in Wikipedia.
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