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For the Soviet air-to-air missile, see Bisnovat R-40
IUPAC name Chloromethane
Other names Monochloromethane, Methyl chloride, Artic, Freon 40, R 40, UN 1063
CAS number 74-87-3
PubChem 6327
EINECS number 200-817-4
ChEBI 36014
RTECS number PA6300000
InChI InChI=1/CH3Cl/c1-2/h1H3
Molecular formula CH3Cl
Molar mass 50.49 g/mol
Appearance Colorless gas with a faint sweet odor
Density 2.22 kg/m3 (0 °C)
Melting point

−97.7 °C (176 K)

Boiling point

-24.2 °C (249 K)

Solubility in water 5.325 g/l
log P 0.91
Vapor pressure 490 kPa (20 °C)
Molecular shape Tetrahedral
MSDS External MSDS
EU classification Extremely flammable (F+), Harmful (Xn), Carc. Cat. 3
NFPA 704
R-phrases R10, R40, R48/20
S-phrases S9, S16, S33
Flash point -46 °C
625 °C
Supplementary data page
Structure and
n, εr, etc.
Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Chloromethane, also called Methyl chloride, or simply R-40 or HCC 40, is a chemical compound once widely used as a refrigerant. It is a colorless extremely flammable gas with a slightly sweet odor, which is, however, detected at possibly toxic levels. Due to concerns about its toxicity, it is no longer present in consumer products.

Methyl chloride was first synthesized by the French chemists Jean-Baptiste Dumas and Eugene Peligot in 1835 by boiling a mixture of methanol, sulfuric acid, and sodium chloride. This method is similar to that used today.



Large amounts of methyl chloride are produced naturally in the oceans by the action of sunlight on biomass and chlorine in sea foam. However, all methyl chloride that is used in industry is produced synthetically.

Most methyl chloride is prepared by reacting methanol with hydrogen chloride, according to the chemical equation

CH3OH + HCl → CH3Cl + H2O

This can be carried out either by bubbling hydrogen chloride gas through boiling methanol with or without a zinc chloride catalyst, or by passing combined methanol and hydrogen chloride vapors over an alumina catalyst at 350 °C.

A smaller amount of methyl chloride is produced by heating a mixture of methane and chlorine to over 400 °C. However, this method also results in more highly chlorinated compounds such as methylene chloride and chloroform and is usually only used when these other products are also desired.


Formerly, methyl chloride was a widely used refrigerant, but due to its toxicity this use has been discontinued. Methyl chloride was also once used for producing lead-based additives for gasoline, but leaded gasoline has been phased out in most of the industrialized world (an important exception being the former Soviet Union).

The most important use of methyl chloride today is as a chemical intermediate in the production of silicone polymers. Smaller quantities are used as a solvent in the manufacture of butyl rubber and in petroleum refining.

Methyl chloride is also employed as a methylating and chlorinating agent in organic chemistry. It is also used in a variety of other fields: as an extractant for greases, oils and resins, as a propellant and blowing agent in polystyrene foam production, as a local anesthetic, as an intermediate in drug manufacturing, as a catalyst carrier in low temperature polymerization, as a fluid for thermometric and thermostatic equipment and as a herbicide.


Inhalation of methyl chloride gas produces central nervous system effects similar to intoxication. Victims may feel drowsy, dizzy, or confused and have difficulty breathing, with gasping and choking, walking or speaking. At higher concentrations, paralysis, seizures, and coma may result.

In case of ingestion nausea and vomiting may result. Skin contact when in the form of a refrigerated liquid may result in frostbite. Contact with eyes may result in dim vision, widely dilated pupils that react slowly to changes in light.

Chronic exposure to methyl chloride has been linked to birth defects in mice. In humans, exposure to methyl chloride during pregnancy may cause the fetus' lower spinal column, pelvis, and legs to form incorrectly, but this has not been conclusively proven.

In 1997, a re-investigation of Boston's Cocoanut Grove nightclub fire cited a methyl chloride leak from a refrigerator as a major cause of that disaster.

See also

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Chloromethane". A list of authors is available in Wikipedia.
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