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Derepression of ALA synthase
Additional recommended knowledge
One example is the effect of drugs on the activity of ALA synthase, an enzyme involved in heme-synthesis. When inducing for example phenobarbital, griseofulvin or hydantoins, the activity of ALA synthase will rise. The cause is a production of cytochrome P450-production, induced by the drugs, consuming heme. When the amount of heme in the liver decreases, it no longer act as a repressor for its synthesis. On the contrary, ALA synthase increases which leads to an increase in heme-production.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Derepression". A list of authors is available in Wikipedia.|