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Enaptin (UniProt name: SYNE1_HUMAN; accession number: Q8NF91) is a nuclear envelope protein found in human myocytes and synapses, which is made up of 8,797 amino acids. Post-translational amino acid modifications can be possible. Enaptin is in the fairest sense involved in the maintenance of nuclear organization and structural integrity, tethering the cell nucleus to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Enaptin has a remarkable structure with a coiled alpha-helical region and a large beta-sheet region in the upper part and at least 4 alpha-helices spliced into each other indicating the similarity with collagen. The structural integrity of Enaptin can be shown by determining whether the protein forms a condensed supramolecule.
Additional recommended knowledge
The molecular weight of the mature protein is approximately 1,011,041.95 Da, and it has a theoretical pI of 5.38 . The following results do not take into account any annotated post-translational modification. The protein's chemical formula is C44189H71252N12428O14007S321. It has a theoretical Instability Index (II) of 51.63, indicating that it would be unstable in a test tube. The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to disappear after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes). 
The protein is made up of three main parts, as can be seen in the diagram: cytoplasmic (1-8746), anchor for type IV membrane protein (8747-8767), and the sequence for perinuclear space (8768-8797). The region in the perinuclear space contains a KASH domain (Klarsicht, ANC-1, Syne Homology).
Amino acid composition
The following table lists the amino acids present in the protein in alphabetical order, along with a count of each, and its contribution to the total count (determined either by weight of thehi hydrosylate or by decomposition of the isolated amino acids).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Enaptin". A list of authors is available in Wikipedia.|