My watch list  

Multi-component reaction

In chemistry, a multi-component reaction (or MCR) is a chemical reaction where three or more compounds react to form a single product.[1]

Examples of three component reactions:

Examples of four component reactions:

The exact nature of this type of reaction is often difficult to assess, in collision theory a simultaneous interaction of 3 or more different molecules is less likely resulting in a low reaction rate. These reactions are more likely to involve a series of bimolecular reactions.

New MCR's are found by building a chemical library from combinatorial chemistry or by combining existing MCR's.[2] For example, a 7-component MCR results from combining the Ugi reaction with the Asinger reaction.[3] MCR's are an important tool in new drug discovery.

See also


  1. ^Armstrong1996  Armstrong, R. W.; Combs, A. P.; Tempest, P. A.; Brown, S. D.; Keating, T. A. Acc. Chem. Res. 1996, 29, 123-131.
  2. ^  Recent progress in the chemistry of multicomponent reactions Ivar Ugi Pure Appl. Chem. 2001, 73, 187-191. (Online article)
  3. ^  The discovery of new isocyanide-based multi-component reactions Alexander Dömling Current Opinion in Chemical Biology 2000, 4, 318-323. (Online article)
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Multi-component_reaction". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE