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PEG 400



Polyethylene glycol
Chemical name Polyethylene glycol
Chemical formula C2nH4n+2On+1, n = 8.2 to 9.1
Molecular mass 380-420 g/mol
CAS number [25322-68-3]
Density 1.128 g/cm³
Viscosity 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Melting point 4-8 °C
Flash Point 238 °C
LD50 30 mL/kg, orally in rats
Disclaimer and references

PEG 400 (Polyethylene Glycol 400) is a low molecular weight grade of Polyethylene glycol. It is a clear, colorless, viscous liqid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.


Additional Properties

PEG 400 is strongly hydrophilic. The partition coefficient of polyethylene glycol 414 between hexane and water is 0.000015 (log P = − 4.8), indicating that when polyethylene glycol 414 is mixed with water and hexane, there are only 1.5 parts of polyethylene glycol 414 in the hexane layer per 100,000 parts of polyethylene glycol 414 in the water layer.[1]

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons.

References

  1. ^ T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology 98 (1): 39-46.
  • The Merck Index, 11th Edition
  • Handbook of Pharmaceutical Excipients
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "PEG_400". A list of authors is available in Wikipedia.
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