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Rizatriptan



Rizatriptan
Systematic (IUPAC) name
N,N-dimethyl-2- [5-(1,2,4-triazol-1-ylmethyl)- 1H-indol-3-yl]ethanamine
Identifiers
CAS number 145202-66-0
ATC code N02CC04
PubChem 5078
DrugBank APRD00008
Chemical data
Formula C15H19N5 
Mol. mass 269.345 g/mol
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism by monoamine oxidase
Half life 2–3 hours
Excretion 82% urine; 12% feces
Therapeutic considerations
Pregnancy cat.

C

Legal status
Routes Oral

Rizatriptan (Maxalt®) is a triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Additional recommended knowledge

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

Rizatriptan is available only by prescription in the United States and Canada. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom.

This medication is used to treat acute migraine attacks. It does not prevent future migraine attacks.

Indicated for:

  • migraine headache with or without aura

Contraindications:

Side effects:

Severe:

  • coronary artery vasospasm
  • transient myocardial ischemia
  • myocardial infarction
  • ventricular tachycardia
  • ventricular fibrillation
  • hypertensive crisis

Atypical sensations:

  • paresthesia

Cardiovascular:

  • palpitations
  • syncope
  • hypertension
  • hypotension

Ear, nose, and throat:

  • tinnitus
  • sensitivity to noise
  • sinusitis
  • allergic rhinitis
  • upper respiratory inflammation

Gastrointestinal:

  • diarrhea

Muscular:

  • myalgia

Neurological:

  • phonophobia
  • photophobia

Respiratory:

  • dyspnea

Skin:

  • sweating

Miscellaneous:

  • hypersensitivity
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rizatriptan". A list of authors is available in Wikipedia.
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