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Sodium valproate



Main article: Valproic acid
Sodium valproate
Systematic (IUPAC) name
sodium 2-propylpentanoate
Identifiers
CAS number 1069-66-5
ATC code N03AG01
PubChem 14047
Chemical data
Formula C8H15NaO2 
Mol. mass 166.20 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90–95%
Metabolism 75% by CYP enzymes
Half life 9–18 hours
Excretion 20% excreted as glucuronide
Therapeutic considerations
Pregnancy cat.

D(AU) D(US)

Legal status

POM(UK) -only(US)

Routes Oral, i.v.

Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer. The intravenous formulations are used when oral administration is not possible.

Additional recommended knowledge

Contents

Formulations

Trade names are in bold, followed by the manufacturer.

U.S.

UK and Australia

  • Tablets – Orlept by Wockhardt and Epilim by Sanofi-Aventis.
  • Oral solution – Orlept Sugar Free by Wockhardt and Epilim by Sanofi-Aventis.
  • Syrup – Epilim by Sanofi-Aventis.
  • Intravenous injection – Epilim Intravenous by Sanofi-Aventis.
  • Extended release tablets – Epilim Chrono by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
  • Enteric-coated tablets – Epilim EC200 by Sanofi-synthélabo. A 200 mg sodium valproate enteric-coated tablet.

Germany, Switzerland, Norway

  • Tablets – Orfiril by Desitin Pharmaceuticals
  • Intravenous injection – Orfiril IV by Desitin Pharmaceuticals

South Africa

  • Syrup – Convulex by Byk Madaus
  • Tablets – Epilim by sanofi~synthelabo

Canada

Others

In much of Europe, Depakine and Depakine Chrono are equivalent to Epilim and Epilim Chrono above.

See also

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sodium_valproate". A list of authors is available in Wikipedia.
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