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URB597



URB597
IUPAC name [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
Identifiers
CAS number 546141-08-6
PubChem 1383884
MeSH URB597
Properties
Molecular formula C20H22N2O3
Molar mass 338.4 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

URB597 is a relatively selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH).[1][2] FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. In pre-clinical laboratory tests researchers found URB597 increased the production of endocannabinoids resulting in measurable antidepressant and analgesic effects.[3]

URB597 is also known as KDS-4103. KDS-4103 is being developed by Kadmus Pharmaceuticals, Inc. for clinical trials in humans. Kadmus claims, on their website (linked below) that this class of compounds may have antidepressant, anti-anxiety, and pain-killing effects.

References

  1. ^ "Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.". J Med Chem.. PMID 15456244. Retrieved on 2007-06-14.
  2. ^ "Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes.". Chem Biol.. PMID 16298297. Retrieved on 2007-06-14.
  3. ^ "The fatty-acid amide hydrolase inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.". J Pharmacol Exp Ther.. PMID 17412883. Retrieved on 2007-06-14.
v • d • e
Cannabinoids
Plant cannabinoidsCBD • CBDV • CBN • CBG • CBV • CBL • THC • THC-C4 • 11-Hydroxy-THC • THCV
Synthetic cannabinoidsAjulemic acid • AM251 • CP 55,940 • DMHP • Dronabinol • HU-210 • JWH-133 • Levonantradol • Methanandamide • Nabilone • Nabitan • Parahexyl • Pravadoline • Rimonabant • THC-O-acetate • THC-O-phosphate • WIN 55,212-2
Endogenous cannabinoidsArachidonoyl ethanolamide (Anandamide or AEA) • 2-Arachidonoylglycerol (2-AG) • 2-Arachidonyl glyceryl ether (noladin ether) • Virodhamine • N-arachidonoyl-dopamine (NADA)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "URB597". A list of authors is available in Wikipedia.
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