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2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor. It is an ester formed from the omega-6 fatty acid arachidonic acid and glycerol. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol lipase (DAG). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by monoacylglycerol lipase (MGL) and fatty acid amide hydrolase, with MGL likely being the principle metabolizing enzyme in vivo.
Additional recommended knowledge
It has been found in maternal bovine and human milk.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-Arachidonoylglycerol". A list of authors is available in Wikipedia.|