Novel method to synthesize valuable fluorinated drug compounds

25-Feb-2025 - Researchers from the National University of Singapore (NUS) have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of drug molecules that escaped synthetic preparation for years. By unlocking a pathway to these ...

Chemists synthesize an improved building block for medicines

Chemists overcome a major hurdle in synthesizing a more stable form of heterocycle—a common component of most modern pharmaceuticals

08-Jul-2024 - Chemists have overcome a major hurdle in synthesizing a more stable form of heterocycle—a family of organic compounds that are a common component of most modern pharmaceuticals. The research, which could expand the toolkit available to drug developers in improving the safety profiles of ...

Researchers create new chemical compound to solve 120-year-old problem

Accessing these molecules can have major impacts on agriculture, pharmaceuticals, and electronics

06-May-2024 - For the first time, chemists in the University of Minnesota Twin Cities College of Science and Engineering have created a highly reactive chemical compound that has eluded scientists for more than 120 years. The discovery could lead to new drug treatments, safer agricultural products, and better ...

Electrochemistry Paves the Way: Sustainable Synthesis Method Reveals N-Hydroxy Modifications for Pharmaceuticals

Closing knowledge gaps - new findings on heterocycles

18-Apr-2024 - New highly selective and scalable electro-organic synthesis of novel benzo[e]-1,2,4-thiadiazine-1,1-dioxides which represent an important structural motif of APIs (active pharmaceutical ingredients) modified with a unique N-hydroxy moiety. Recently published research results enable preparative ...

Electrochemistry converts carbon to useful molecules

How a team uses electrosynthesis to turn carbon dioxide into valuable pharmaceutical molecules

09-Jan-2023 - A chemistry collaboration led to a creative way to put carbon dioxide to good – and even healthy – use: by incorporating it, via electrosynthesis, into a series of organic molecules that are vital to pharmaceutical development. In the process, the team made an innovative discovery. By changing ...

Let there be light: Synthesizing organic compounds

23-Sep-2019 - Every biological reaction is a chemical reaction. The exchange of carbon dioxide for oxygen in our lungs and blood cells, for example, is caused by molecules releasing chemicals and reforming with new ones. The uncontrolled replication of cancerous cells is the result of broken chemical compounds ...

Synthesis of medicinally privileged heterocycles through dielectric heating

10-Mar-2017 - Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one ...

Cool combination produces easier carbon bonds

25-Apr-2016 - By combining two century-old techniques in organic chemistry, Syuzanna Harutyunyan is able to make organic compounds with greater ease and precision. Such compounds are important for drug discovery and development. Almost 90 percent of known active pharmaceutical ingredients contain one or more ...

Bidentate Chelates with Larger Spacers

Chelating Lewis acids prepared by double hydroalumination of dialkynylsilanes

10-Nov-2011 - Molecular oligoacceptors (chelating Lewis acids) are interesting compounds that are potentially applicable in phase-transfer processes, catalysis, or molecular recognition. Compounds with two or more coordinatively unsaturated tricoordinate aluminium or gallium atoms in a single molecule are ...

Researchers confirm benzene-like electron delocalization of important molecule

UO team's findings could pave way for synthetic compounds useful in drug discovery and materials science

23-Jun-2008 - Researchers in the lab of University of Oregon chemist Shih-Yuan Liu have successfully synthesized and structurally characterized boron-nitrogen compounds that are isoelectronic and isostructural to the fundamentally important benzene molecule. Given the appearance of benzene derivatives in ...