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27 Current news of Scripps Research Institute
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Chemists develop framework to enable efficient synthesis of 'information-dense' molecules
Researchers harness information theory to better understand how to make complex and compact molecules resembling those in nature
27-Oct-2020
A team led by scientists at Scripps Research has developed a theoretical approach that could ease the process of making highly complex, compact molecules. Such molecules are often found in plants and other organisms, and many are considered desirable starting points for developing potential new ...
'Semi-synthetic' bacteria churn out unnatural proteins
19-Jul-2019
Synthetic biologists seek to create new life with forms and functions not seen in nature. Although scientists are a long way from making a completely artificial life form, they have made semi-synthetic organisms that have an expanded genetic code, allowing them to produce never-before-seen ...
Inhoffen Medal 2019 awarded to specialist for synthetic organic chemistry
08-Apr-2019
Medically relevant compounds can often be found in nature. To make them suitable for drugs, they need to be isolated from their natural sources. If sufficient quantities of the agent cannot be isolated in that manner, chemical synthesis comes into play. Without chemical synthesis, many agents ...
Best of both worlds: Combining two skeleton-building chemical reactions
13-Aug-2018
Scripps Research scientists have developed a powerful new strategy for synthesizing molecular skeletons of chemicals used in drugs and other important products, a technique that provides unprecedented flexibility and control over chemical synthesis. The method, which combines two chemical ...
A plausible recipe for early life on Earth
09-Jan-2018
Chemists at The Scripps Research Institute (TSRI) have developed a fascinating new theory for how life on Earth may have begun. Their experiments demonstrate that key chemical reactions that support life today could have been carried out with ingredients likely present on the planet four billion ...
Potential 'missing link' in chemistry that led to life on earth found
08-Nov-2017
Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth. Origins-of-life researchers have hypothesized that a chemical reaction called phosphorylation may have been crucial for the assembly of three key ...
Making polymer chemistry 'click'
26-Jul-2017
A team of researchers has developed a faster and easier way to make sulfur-containing polymers that will lower the cost of large-scale production. The achievement opens the door to creating new products from this class of polymers while producing far less hazardous waste. The researchers' ...
New method enlists electricity for easier, cheaper, greener chemistry
22-Apr-2016
Scientists at The Scripps Research Institute (TSRI) have found a new and better way to achieve a chemical reaction that is used widely in the pharmaceutical as well as flavor and fragrance industries. Traditional methods of "allylic oxidation" typically employ toxic and/or expensive reagents such ...
Chemists find a way to synthesize complex plant molecule phorbol and its derivatives
30-Mar-2016
In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute (TSRI) have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research. Phorbol has long been considered a sort ...
TSRI chemists achieve new technique with profound implications for drug development
Method expands options for making pure batches of 'one-handed' molecules
27-Oct-2014
Breaking carbon-hydrogen (C-H) bonds to alter existing molecules to create new ones is an increasingly important avenue for drug development. Of particular interest is mirror-image or "one-handed" compounds, but C-H breaking methods for making pure batches of these molecules have worked with only ...
