Pharmaceutical Intermediates

Researchers have developed a new method that aids in the process of making valuable compounds by using a unique combination of catalysts. Huimin Zhao, Professor of Chemical and Biomolecular Engineering and leader of the Biosystems Design research theme at the Carl R. Woese Institute for Genomic Biol more

AMPAC Fine Chemicals LLC (AFC), a subsidiary of American Pacific Corporation announced that it has entered into a manufacturing partnership with Codexis, Inc. Under a new agreement, AFC will partner with Codexis to use Codexis' proprietary biocatalysis technology in combination with AFC's existing more

The first major large-scale project of a multi-step synthesis of a pharmaceutical intermediate in the new 1000-liter-low-temperature reactor has recently been finished at the AllessaSyntec GmbH & Co. KG in Frankfurt-Höchst. “We have proven that the exclusive synthesis of high-value products at a tec more

Conversion of platform molecule 5-hydroxymethylfurfural (HMF) into highvalue-added derivatives has attracted significant interest. FDCA and its esters are important derivatives of HMF, which can be used as polyester monomers and pharmaceutical intermediates. In this paper, the oxidative esterificati more

In the period 1985 to 1995 applications of biocatalysis, driven by the need for more sustainable manufacture of chemicals and catalytic, (enantio)selective methods for the synthesis of pharmaceutical intermediates, largely involved the available hydrolases. This was followed, in the next two decades more

Modification of the sterol catabolism pathway in mycobacteria may result in the accumulation of some valuable steroid pharmaceutical intermediates, such as 9α-hydroxy-4-androstene-3,17-dione (9-OHAD). In previous work, sigma factor D (SigD) was identified as a negative factor of the 9-OHAD productio more