System for lipid nanoparticle formulation research

The IJM NanoScaler system is designed for lipid nanoparticle R&D – allowing scientists to determine the optimal process parameters for the formulation of API-containing lipid nanoparticles. These active pharmaceutical ingredients include complex or delicate API like RNA, mRNA, siRNA, and DNA-based molecules, or products that need specific entry into target cells.

Equipped with KNAUER’s lipid nanoparticle producing Impingement Jets Mixing (IJM) technology the NanoScaler allows researchers to optimize encapsulation conditions for their nucleotide-based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit. The benchtop system comes with five different KNAUER IJM units to help researchers determine optimum encapsulation conditions – custom mixing units can also be used.

The IJM NanoScaler can produce lipid-encapsulated API at a range from 1 mL to hundreds of milliliters meaning the system is perfect for proof-of-concept testing and process optimization, pre-clinical trials e.g. for in vitro studies, as well as small-scale production.