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CAS number 31103-86-3
PubChem 18950
MeSH Mannose
Molecular formula C6H12O6
Molar mass 180.156
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

    Mannose is a sugar monomer of the hexose series of carbohydrates.



Mannose enters the carbohydrate metabolism stream in two steps:

  • First it undergoes phosphorylation to mannose-6-phosphate by hexokinase.
  • Then, it is converted to fructose-6-phosphate by mannose phosphate isomerase.


Mannose can be formed by the oxidation of mannitol.

It can also be formed from D-glucose in the Lobry-de Bruyn-van Ekenstein transformation


The root of both "mannose" and "manitol" is manna, which the Bible records as the food supplied to the Israelites during their journey through the Sinai Peninsula. Manna is a sweet secretion of several trees and shrubs, such as Fraxinus ornus.

Cranberry juice

D-Mannose, which appears in some fruits including cranberry, has been postulated to prevent the adhesion of bacteria to the epithelium of the urinary tract and Urinary bladder through a mechanism presumed to be competitive in nature with the polysaccharide coating of the cystic epithelium. While no studies have objectively verified this mechanism, anecdotal reports from patients show some improvement in symptoms.[citation needed]


The fact that D-mannose has the same configuration at its penultimate carbon as D-glyceraldehyde is unsurprising as that is what defines the dextro classification. However, mannose differs from D-glucose by inversion of the C2 chiral centre. This apparently simple change leads to the drastically different chemistry of the two hexoses, as it does the remaining six hexoses.

See also


    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mannose". A list of authors is available in Wikipedia.
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