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Phosphofructokinase-1 (PFK-1) is the most important regulatory enzyme (EC 126.96.36.199) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. PFK-1 catalyzes one of the important "committed" steps of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP.
Additional recommended knowledge
This step is subject to extensive regulation since it is not only irreversible, but also because the original substrate is forced to proceed down the glycolytic pathway after this step. This leads to a precise control of glucose and the other monosaccharides galactose and fructose going down the glycolysis pathway. Before this enzyme's reaction, glucose-6-phosphate can potentially travel down the pentose phosphate pathway, or be converted to glucose-1-phosphate and polymerized into the storage form Glycogen.
PFK1 is allosterically inhibited by ATP and citrate (from the citric acid cycle) and its product. It is also inhibited by low pH to prevent the accumulation of hydrogen ions in muscle. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.
PFK is inhibited by glucagon through repression of synthesis.
There are three phosphofructokinase genes in humans:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phosphofructokinase_1". A list of authors is available in Wikipedia.|