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Pravastatin



Pravastatin
Systematic (IUPAC) name
3,5-dihydroxy-7- [6-hydroxy-2-methyl-8- (2-methylbutanoyloxy)- 1,2,6,7,8,8a- hexahydronaphthalen-1-yl]- heptanoic acid
Identifiers
CAS number 81093-37-0
ATC code C10AA03
PubChem 54687
DrugBank APRD00328
Chemical data
Formula C23H36O7 
Mol. mass 424.528 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 50%
Metabolism  ?
Half life 77 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

In medicine and pharmacology, pravastatin (Pravachol® or Selektine®) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.

Additional recommended knowledge

Pravastatin was identified originally in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc. It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.

In 2003, Bristol-Myers Squibb announced in a magazine advertisement that pravastatin is no longer the only statin approved by the FDA proven to reduce the risk of cardiovascular disease, and that rosuvastatin, another statin, is approved to reduce this risk.

The U.S. Food and Drug Administration approved a generic version of Pravastatin for sale in the United States for the first time on April 24, 2006. Generic Pravastatin Sodium Tablets (10mg, 20mg and 40mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel. FDA Press Release

In 2005, Pravachol was the 22nd highest-selling brand-name drug in the United States. FDA Press Release

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pravastatin". A list of authors is available in Wikipedia.
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