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Benfluorex



Benfluorex
Systematic (IUPAC) name
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]
ethyl benzoate
Identifiers
CAS number 23602-78-0
ATC code C10AX04
PubChem 2318
Chemical data
Formula C19H20F3NO2 
Mol. mass 351.363 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Oral

Benfluorex is an anorectic and hypolipidemic agent. Clinical studies have shown it may improve glycemic control and decrease insulin resistance in people with poorly controlled type 2 diabetes;[1][2] it is marketed in France as an adjuvant antidiabetic.

Additional recommended knowledge

Benfluorex is structurally related to fenfluramine.

References

  1. ^ Moulin P, Andre M, Alawi H, et al (2006). "Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study". Diabetes Care 29 (3): 515–20. PMID 16505498. Free full text
  2. ^ Roger P, Auclair J, Drain P (1999). "Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind study versus placebo". J Diabetes Complications 13 (2): 62–7. PMID 10432168.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benfluorex". A list of authors is available in Wikipedia.
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