My watch list
my.chemeurope.com  
Login  

Etofibrate



Etofibrate
Systematic (IUPAC) name
2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]oxy}ethyl nicotinate
Identifiers
CAS number 31637-97-5
ATC code C10AB09
PubChem 65777
Chemical data
Formula C18H18ClNO5 
Mol. mass 363.792 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hydrolyzed to clofibric acid and niacin
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.[1]

Additional recommended knowledge

References

  1. ^ Sposito AC, Mansur AP, Maranhão RC, Rodrigues-Sobrinho CR, Coelho OR, Ramires JA (2001). "Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects". Braz J Med Biol Res 34 (2): 177–82. PMID 11175492. Free full text


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Etofibrate". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE