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Etofibrate


Etofibrate
Systematic (IUPAC) name
2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]oxy}ethyl nicotinate
Identifiers
CAS number	31637-97-5
ATC code	C10AB09
PubChem	65777
Chemical data
Formula	C₁₈H₁₈Cl N O₅
Mol. mass	363.792 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hydrolyzed to clofibric acid and niacin
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.^[1]

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References

^ Sposito AC, Mansur AP, Maranhão RC, Rodrigues-Sobrinho CR, Coelho OR, Ramires JA (2001). "Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects". Braz J Med Biol Res 34 (2): 177–82. PMID 11175492. Free full text

v • d • e Lipid modifying agents (C10)
Statins	Atorvastatin • Cerivastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Simvastatin
Fibrates	Clofibrate • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride
Bile acid sequestrants	Colestyramine • Colestipol • Colextran • Colesevelam
Niacin and derivatives	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox
Other	Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Ezetimibe