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Secretin receptor family

Secretin family of 7 transmembrane receptors
Symbol 7tm_2
Pfam PF00002
InterPro IPR000832
SCOP 1bl1
OPM family 6
OPM protein 1fjr
Available PDB structures:

PDB 1bl1 ; 17-30; PDB 1et2 S 184-46 PDB 1et3 S 184-46

Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.[1]

This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors.They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated by peptide hormoness from the glucagon hormone family.

The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors, all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.

Additional recommended knowledge


Subfamily B1

Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

  • Adenylate cyclase-activating type 1 receptor, pituitary IPR002285
    • ADCYAP1R1
  • Calcitonin receptor IPR003287
  • Corticotropin-releasing hormone receptor IPR003051
    • CRHR1; CRHR2
  • Glucagon receptor-related IPR003290
    • GLP1R; GLP2R; GPCR
  • Growth hormone releasing hormone receptor IPR003288
    • GHRHR
  • Parathyroid hormone receptor IPR002170
    • PTHR1; PTHR2
  • Secretin receptor IPR002144
    • SCTR
  • Vasoactive intestinal peptide receptor IPR001571
    • VIPR1; VIPR2

Subfamily B2

Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin (such as UniProt O94910, and brain-specific angiogenesis inhibitor receptors (such as UniProt O14514) amongst others.

  • Brain-specific angiogenesis inhibitor IPR008077
    • BAI1; BAI2; BAI3
  • CD97 antigen IPR003056
    • CD97
  • EMR hormone receptor IPR001740
  • Gastric inhibitory polypeptide receptor IPR001749
    • GCGR; GIPR
  • GPR56 orphan receptor IPR003910
    • GPR56; GPR64; GPR97; GPR110; GPR111; GPR112; GPR113; GPR114; GPR115; GPR123; GPR125; GPR126; GPR128; GPR133; GPR144; GPR157
  • Latrophilin receptor IPR003924
    • ELTD1; LPHN1; LPHN2; LPHN3

Subfamily B3

Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

  • Diuretic hormone receptor IPR002001

Unclassified subfamilies

  • Ig-hepta receptor IPR008078
    • GPR116

Unclassified members

DREG; HCTR-5; HCTR-6; KPG_003; KPG_006; KPG_008; KPG_009; RESDA1


  1. ^ Harmar AJ (2001). "Family-B G-protein-coupled receptors". Genome Biol. 2 (12): REVIEWS3013. doi:10.1186/gb-2001-2-12-reviews3013. PMID 11790261.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Secretin_receptor_family". A list of authors is available in Wikipedia.
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