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Theaflavin and its derivatives, known collectively as theaflavins, are polyphenols Flavan-3-ols that are formed from catechins such as in tea leaves during the enzymatic oxidation (called fermentation by the tea trade) of tea leaves, such as in black tea. Several tea polyphenols, especially those with galloyl moiety, can inhibit HIV-1 replication with multiple mechanisms of action. It is showed that the theaflavin derivatives had more potent anti-HIV-1 activity than catechin derivatives.
Additional recommended knowledge
Epigallocatechin gallate (EGCG), a catechin in green tea, binds to gp120, which works in conjunction with gp41 of HIV to enter into healthy human immune cells. Like EGCG, Theaflavins and Thearubigins compounds found in black teas penetrate the blood brain barrier, and have been shown to be effective against dementia in aging as well as AIDS related dementia plaques in vitro. Since modern anti-retroviral meds do not reach the brain, HIV can maintain reservoirs for reinfection.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Theaflavin". A list of authors is available in Wikipedia.|