Synthesis

Companies Synthesis

Chemspeed Technologies AG, Switzerland

Chemspeed is a global leader in the development of innovative instruments and consumables for scientists working in research and development laboratories including a line of fully automated parallel synthesizers, instruments for high throughput solid dispensing and liquid handling, and workstations more

MLS GmbH, Germany

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CEM GmbH, Germany

CEM is the leading provider of microwave solutions for the laboratory, industrial and scientific marketplace. Since creating this market 20 years ago, we have sold almost 20,000 systems. Despite this obvious success, we believe microwave chemistry is still an emerging technology and presents tremend more

Products Synthesis

Integrated Flow Chemistry System … carry out reactions up to 260°C, 100 bar and 20 ml/min

Realise the full benefits of flow chemistry more

High Throughput Flow Reactor for Process Chemists

The FlowSyn Maxi™ from Uniqsis is a high throughput flow reactor for process chemists looking to optimise reaction conditions before scaling-up synthetic production to multiple kilograms per day more

Preparative HPLC: Flexibility Meets Convenience

The unique Azura prep HPLC systems: Multifunctional preparative HPLC systems you can easily adapt to specific sample purification challenges more

News Synthesis

• Selective conversion of reactive lithium compounds made possible
  

  Researchers at Ruhr-Universität Bochum have developed a new catalyst that can catalyse reactions to produce pharmaceuticals or chemicals used in agriculture. It creates carbon-carbon bonds between what are known as organolithium compounds without creating any unwanted by-products. The team led by Pr more

• Template-Free Synthesis of Mesoporous β-MnO2 Nanoparticles
  

  Scientists at Tokyo Institute of Technology explore a novel and simplistic method to synthesize manganese dioxide with a specific crystalline structure called β-MnO2. Their study sheds light on how different synthesis conditions can produce manganese dioxide with distinct porous structures, hinting more

• Insights into the structure of an enigmatic catalyst
  

  In the past, the catalyst for the production of methanol had eluded all attempts to clarify its surface structure. Now researchers have learned more about its active site. Methanol is one of the most important basic chemicals used, for example, to produce plastics or building materials. To render th more

Videos Synthesis

Berghof reactor technology - high- and low-pressure reactors, pressure vessels and metal-free reactors

NR low-pressure reactors, DB metal-free reactors and DAB pressure vessels.Smart instrument concepts allow an easy handling of all Berghof reactors. Due to helpful tools, opening and closure of the reactors is fast and with few effort. Extensive accessories support an efficient use of the reactors.Ru more

Improve Your Strategy for the Design of New Molecules

Science of Synthesis is your one-stop tool for full-text reviews of organic transformations and experimental procedures. The online reference work helps speed up your literature research and improve your strategy for the design of new molecules. Science of Synthesis provides a critical review of the more

Increased synthesis lab productivity through greener and faster flash purification

Biotage® Selekt and Sfär - Flash purification system and consumables more

White papers Synthesis

• Innovative Techniques to Synthesize Breakthrough Molecules
  

  Four case studies highlight how top pharmaceutical companies are implementing new synthesis techniques and the impact on the chemical synthesis lab more

• In Situ Monitoring of Chemical Reactions – A Molecular Video
  

  While the technique has gained increased popularity in recent times, the principal of in situ reaction monitoring dates back to 1961 when Farenfort introduced a new method of measurement that today is called Attenuated Total Reflectance (ATR). The co more

• Pfizer Evaluates New Automated Sampling Technique
  

  This paper reviews the advantages of automated sampling, and four case studies testing the practice of EasySampler at Pfizer for impurity profiling more

Publications Synthesis

• Silver(I)-catalyzed sequential hydroamination and Prins type cyclization for the synthesis of fused benzo--sultams

  An intramolecular annulation strategy has been developed for the synthesis of tetrahydrobenzo[e]pyrano[4,3-c][1,2]thiazine derivatives by means of coupling of aldehydes with 2-(4-hydroxybut-1-yn-1-yl)-N-arylsulfonamides using a catalytic amount of silver hexafluoroantimonate in toluene at 80 °C. Thi more

• An efficient iodine pentoxide-triggered iodocarbocyclizations for the synthesis of iodooxindoles in water

  An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was us more

• Copper-Catalyzed Cyclization of 2-Cyanobenzaldehydes and 2-Isocyanoacetates: an Efficient Strategy for the Synthesis of Substituted 1-Aminoisoquinolines

  A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinoline. The reaction proceeds smoothly under mild conditions with high efficiency, and might provid more

q&more articles Synthesis

• The Beginning of the End?
  

  Those of us who have been either directly involved in, or on the periphery of, the pharmaceutical industry over the last decade have seen at first hand a dramatic change. Times change, and technology changes. Take computer data storage for example. Not so long ago, the floppy disk was state of the art, replaced by the CD-ROM, and then by the USB drive. more

• Modular biofactories at the cellular level
  

  Despite his love for complex molecular architectures, this „dyed-in-the-wool“ bio-organic chemist has never embraced the conventional segregation of synthetic polymers and bio­logical macromolecules. All molecules are composed of atoms, after all. Why make an artificial distinction? Why not simply combine these domains together? more

• With Light in the Fight against Malaria
  

  Malaria represents a global threat to health, which is difficult to keep under control. Amongst more than 200 million sufferers, over 500,000 die each year of the disease, with the risk of a fatal outcome being particularly high in children [1]. more

Authors Synthesis

• Prof. Dr. Burkhard König
  

  Burkhard König, born in 1963, received his Ph.D. in 1991 from the University of Hamburg. He continued his scientific education as a post-doctoral fellow with Prof. M. A. Bennett, Research School of Chemistry, Australian National University, Canberra, and Prof. B. M. Trost, Stanford University. Since more

• Mathies V. Evers
  

  Mathies Evers, born in 1989, studied chemistry at the Ruhr University Bochum, where he researched the synthesis of atom-precise molecular clusters. After his master's degree he started his doctoral thesis at the Chair of Analytical Chemistry II of Professor Dr. Kristina Tschulik and is supported by more

• Prof. Dr. Peter Seeberger
  

  born 1966, studied chemistry at the University of Erlangen-Nuremberg, and received his doctorate in biochemistry from the University of Colorado. After holding a post-doctorate position at the Sloan-Kettering Institute for Cancer Research in New York City, he was Assistant Professor and Firmenich As more