Synthesis

Companies Synthesis

MLS GmbH, Germany

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CEM GmbH, Germany

CEM is the leading provider of microwave solutions for the laboratory, industrial and scientific marketplace. Since creating this market 20 years ago, we have sold almost 20,000 systems. Despite this obvious success, we believe microwave chemistry is still an emerging technology and presents tremend more

Chemspeed Technologies AG, Switzerland

Chemspeed is a global leader in the development of innovative instruments and consumables for scientists working in research and development laboratories including a line of fully automated parallel synthesizers, instruments for high throughput solid dispensing and liquid handling, and workstations more

Products Synthesis

New microwave synthesis with lots of power, camera and accessories

The Discover® 2.0 is the premier microwave reactor for performing any organic or inorganic synthetic chemistry. Featuring a best-in-class 300 mL single more

Cyrene™ Bio-Renewable Dipolar Aprotic Solvent

Better for nature: 99% biodegradation in 28 days ✓ Better for users: No mutagenic or genotoxic risks ✓ Better performance: Optimum polarity & high viscosity more

Buchi nutsche filters for various applications in scale-up, pilot and production

Easy and safe operation ✓ Customized according to your process requirements ✓ cGmP and ATEX compliant ✓ more

News Synthesis

• Silicon with a Two-Dimensional Structure
  

  Silicon, a semi-metal, bonds in its natural form with four other elements and its three-dimensional structure takes the form of a tetrahedron. For a long time, it seemed impossible to achieve the synthesis and characterisation of a two-dimensional equivalent – geometrically speaking, a square. Now s more

• How Green Is Your Plastic?
  

  Despite the best efforts of industry to work towards sustainability, most plastics (or polymers) are still made using non-renewable fossil fuels. However, researchers have now found an economical method for producing biobased acrylate resins. The study, published in the journal Angewandte Chemie, sh more

• The AETX files: Work to unravel widespread bald eagle fatalities gathers pace
  

  This March, the discovery of the toxic natural substance aetocthonotoxin (AETX) attracted huge media attention. In a study published in Science, pharmacists from Halle University proved the role of this substance in triggering mass species extinctions among American bald eagles and other birds of pr more

Videos Synthesis

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

CEM Corporation is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue microwave peptide synthesizer. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of t more

Narrow PSD Spherical Particles in Micron Range by Drying / Core-Shell Coating / Calcination in One Step

From nano to micro: drying, coating and calcining in just one process step with synthesis reactors from Glatt. Produce and coat powder materials with new, previously unattained properties in the pulsating hot gas stream of the patented Glatt powder synthesis. Thanks to the particularly homogeneous t more

Berghof reactor technology - high- and low-pressure reactors, pressure vessels and metal-free reactors

NR low-pressure reactors, DB metal-free reactors and DAB pressure vessels.Smart instrument concepts allow an easy handling of all Berghof reactors. Due to helpful tools, opening and closure of the reactors is fast and with few effort. Extensive accessories support an efficient use of the reactors.Ru more

White papers Synthesis

• Innovative Techniques to Synthesize Breakthrough Molecules
  

  Four case studies highlight how top pharmaceutical companies are implementing new synthesis techniques and the impact on the chemical synthesis lab more

• Develop Syntheses More Efficiently: How to Save Time and Money by Laboratory Automation
  

  How to maximize the efficiency and quality of developing your synthesis through parallel method development using fully automated laboratory reactors more

• Pfizer Evaluates New Automated Sampling Technique
  

  This paper reviews the advantages of automated sampling, and four case studies testing the practice of EasySampler at Pfizer for impurity profiling more

Job offers Synthesis

• Chemist (m/f/d) as Research Scientist
  

  The global Research Center Surfactants is looking for a motivated and creative Chemist (m/f/d) who can strengthen the execution of our innovation strategy. In our Research Site in Burgkirchen (Bavaria), Germany, you will be working in a synthesis laboratory and supporting innovation projects in an i more

Publications Synthesis

• Silver(I)-catalyzed sequential hydroamination and Prins type cyclization for the synthesis of fused benzo--sultams

  An intramolecular annulation strategy has been developed for the synthesis of tetrahydrobenzo[e]pyrano[4,3-c][1,2]thiazine derivatives by means of coupling of aldehydes with 2-(4-hydroxybut-1-yn-1-yl)-N-arylsulfonamides using a catalytic amount of silver hexafluoroantimonate in toluene at 80 °C. Thi more

• An efficient iodine pentoxide-triggered iodocarbocyclizations for the synthesis of iodooxindoles in water

  An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was us more

• Copper-Catalyzed Cyclization of 2-Cyanobenzaldehydes and 2-Isocyanoacetates: an Efficient Strategy for the Synthesis of Substituted 1-Aminoisoquinolines

  A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinoline. The reaction proceeds smoothly under mild conditions with high efficiency, and might provid more

q&more articles Synthesis

• Customized ligands pave the way for new reaction pathways
  

  For the first time, an efficient catalyst for palladium-catalyzed C–C bonding between aryl chlorides and alkyl lithium compounds has been found. This reaction enables simpler synthesis routes for important products, such as pharmaceuticals, while avoiding much salt waste. more

• The Beginning of the End?
  

  Those of us who have been either directly involved in, or on the periphery of, the pharmaceutical industry over the last decade have seen at first hand a dramatic change. Times change, and technology changes. Take computer data storage for example. Not so long ago, the floppy disk was state of the art, replaced by the CD-ROM, and then by the USB drive. more

• With Light in the Fight against Malaria
  

  Malaria represents a global threat to health, which is difficult to keep under control. Amongst more than 200 million sufferers, over 500,000 die each year of the disease, with the risk of a fatal outcome being particularly high in children [1]. more

Authors Synthesis

• Prof. Dr. Peter Seeberger
  

  born 1966, studied chemistry at the University of Erlangen-Nuremberg, and received his doctorate in biochemistry from the University of Colorado. After holding a post-doctorate position at the Sloan-Kettering Institute for Cancer Research in New York City, he was Assistant Professor and Firmenich As more

• Mathies V. Evers
  

  Mathies Evers, born in 1989, studied chemistry at the Ruhr University Bochum, where he researched the synthesis of atom-precise molecular clusters. After his master's degree he started his doctoral thesis at the Chair of Analytical Chemistry II of Professor Dr. Kristina Tschulik and is supported by more

• Prof. Dr. Burkhard König
  

  Burkhard König, born in 1963, received his Ph.D. in 1991 from the University of Hamburg. He continued his scientific education as a post-doctoral fellow with Prof. M. A. Bennett, Research School of Chemistry, Australian National University, Canberra, and Prof. B. M. Trost, Stanford University. Since more