Synthesis

Companies Synthesis

MLS GmbH, Germany

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Chemspeed Technologies AG, Switzerland

Chemspeed is a global leader in the development of innovative instruments and consumables for scientists working in research and development laboratories including a line of fully automated parallel synthesizers, instruments for high throughput solid dispensing and liquid handling, and workstations more

CEM GmbH, Germany

CEM is the leading provider of microwave solutions for the laboratory, industrial and scientific marketplace. Since creating this market 20 years ago, we have sold almost 20,000 systems. Despite this obvious success, we believe microwave chemistry is still an emerging technology and presents tremend more

Products Synthesis

Cyrene™ Bio-Renewable Dipolar Aprotic Solvent

Better for nature: 99% biodegradation in 28 days ✓ Better for users: No mutagenic or genotoxic risks ✓ Better performance: Optimum polarity & high viscosity more

Look up Industrial Syntheses of 2,600 APIs

One-stop source of information relating to the industrial synthesis and commercial applications of every licensed drug of significance more

High Throughput Flow Reactor for Process Chemists

The FlowSyn Maxi™ from Uniqsis is a high throughput flow reactor for process chemists looking to optimise reaction conditions before scaling-up synthetic production to multiple kilograms per day more

News Synthesis

• Abandoning the old ways: Progress in the low-cost electrochemical synthesis of ammonia
  

  Ammonia (NH3) is among the most important chemicals produced by humans and has a promising future in sustainable energy applications besides being used in fertilizer production. Unfortunately, so far, the only realistic way that exists to produce ammonia at an industrial scale is through the Haber-B more

• Breakthrough in the production of three-dimensional molecular structures
  

  A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in c more

• Virtual lab finds the right AI tool for each chemistry problem
  

  Having the right tool for the job makes the job a lot easier, less expensive and faster. Chemical engineering researchers have now developed a virtual laboratory that can be used to determine the artificial intelligence (AI) tools best suited for addressing various chemical synthesis challenges in f more

Videos Synthesis

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

CEM Corporation is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue microwave peptide synthesizer. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of t more

Narrow PSD Spherical Particles in Micron Range by Drying / Core-Shell Coating / Calcination in One Step

From nano to micro: drying, coating and calcining in just one process step with synthesis reactors from Glatt. Produce and coat powder materials with new, previously unattained properties in the pulsating hot gas stream of the patented Glatt powder synthesis. Thanks to the particularly homogeneous t more

Berghof reactor technology - high- and low-pressure reactors, pressure vessels and metal-free reactors

NR low-pressure reactors, DB metal-free reactors and DAB pressure vessels.Smart instrument concepts allow an easy handling of all Berghof reactors. Due to helpful tools, opening and closure of the reactors is fast and with few effort. Extensive accessories support an efficient use of the reactors.Ru more

White papers Synthesis

• In Situ Monitoring of Chemical Reactions – A Molecular Video
  

  While the technique has gained increased popularity in recent times, the principal of in situ reaction monitoring dates back to 1961 when Farenfort introduced a new method of measurement that today is called Attenuated Total Reflectance (ATR). The co more

• Pfizer Evaluates New Automated Sampling Technique
  

  This paper reviews the advantages of automated sampling, and four case studies testing the practice of EasySampler at Pfizer for impurity profiling more

• Innovative Techniques to Synthesize Breakthrough Molecules
  

  Four case studies highlight how top pharmaceutical companies are implementing new synthesis techniques and the impact on the chemical synthesis lab more

Publications Synthesis

• Silver(I)-catalyzed sequential hydroamination and Prins type cyclization for the synthesis of fused benzo--sultams

  An intramolecular annulation strategy has been developed for the synthesis of tetrahydrobenzo[e]pyrano[4,3-c][1,2]thiazine derivatives by means of coupling of aldehydes with 2-(4-hydroxybut-1-yn-1-yl)-N-arylsulfonamides using a catalytic amount of silver hexafluoroantimonate in toluene at 80 °C. Thi more

• An efficient iodine pentoxide-triggered iodocarbocyclizations for the synthesis of iodooxindoles in water

  An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was us more

• Copper-Catalyzed Cyclization of 2-Cyanobenzaldehydes and 2-Isocyanoacetates: an Efficient Strategy for the Synthesis of Substituted 1-Aminoisoquinolines

  A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinoline. The reaction proceeds smoothly under mild conditions with high efficiency, and might provid more

q&more articles Synthesis

• Modular biofactories at the cellular level
  

  Despite his love for complex molecular architectures, this „dyed-in-the-wool“ bio-organic chemist has never embraced the conventional segregation of synthetic polymers and bio­logical macromolecules. All molecules are composed of atoms, after all. Why make an artificial distinction? Why not simply combine these domains together? more

• The Beginning of the End?
  

  Those of us who have been either directly involved in, or on the periphery of, the pharmaceutical industry over the last decade have seen at first hand a dramatic change. Times change, and technology changes. Take computer data storage for example. Not so long ago, the floppy disk was state of the art, replaced by the CD-ROM, and then by the USB drive. more

• Customized ligands pave the way for new reaction pathways
  

  For the first time, an efficient catalyst for palladium-catalyzed C–C bonding between aryl chlorides and alkyl lithium compounds has been found. This reaction enables simpler synthesis routes for important products, such as pharmaceuticals, while avoiding much salt waste. more

Authors Synthesis

• Mathies V. Evers
  

  Mathies Evers, born in 1989, studied chemistry at the Ruhr University Bochum, where he researched the synthesis of atom-precise molecular clusters. After his master's degree he started his doctoral thesis at the Chair of Analytical Chemistry II of Professor Dr. Kristina Tschulik and is supported by more

• Prof. Dr. Burkhard König
  

  Burkhard König, born in 1963, received his Ph.D. in 1991 from the University of Hamburg. He continued his scientific education as a post-doctoral fellow with Prof. M. A. Bennett, Research School of Chemistry, Australian National University, Canberra, and Prof. B. M. Trost, Stanford University. Since more

• Prof. Dr. Peter Seeberger
  

  born 1966, studied chemistry at the University of Erlangen-Nuremberg, and received his doctorate in biochemistry from the University of Colorado. After holding a post-doctorate position at the Sloan-Kettering Institute for Cancer Research in New York City, he was Assistant Professor and Firmenich As more