Synthesis

Companies Synthesis

MLS GmbH, Germany

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Chemspeed Technologies AG, Switzerland

Chemspeed is a global leader in the development of innovative instruments and consumables for scientists working in research and development laboratories including a line of fully automated parallel synthesizers, instruments for high throughput solid dispensing and liquid handling, and workstations more

CEM GmbH, Germany

CEM is the leading provider of microwave solutions for the laboratory, industrial and scientific marketplace. Since creating this market 20 years ago, we have sold almost 20,000 systems. Despite this obvious success, we believe microwave chemistry is still an emerging technology and presents tremend more

Products Synthesis

Buchi lab and pilot pressure reactors - customized solutions for your process requirements.

Built according to your specifications using highly corrosion resistant materials. ✓ Modular setup for customized configuration and easy upgradability. ✓ Smart design features allows for safe & effortless handling and operation. ✓ more

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

Cyrene™ Bio-Renewable Dipolar Aprotic Solvent

Better for nature: 99% biodegradation in 28 days ✓ Better for users: No mutagenic or genotoxic risks ✓ Better performance: Optimum polarity & high viscosity more

News Synthesis

• Materials synthesis research and study in terapascal range for the first time
  

  Jules Verne could not even dream of this: A research team from the University of Bayreuth, together with international partners, has pushed the boundaries of high-pressure and high-temperature research into cosmic dimensions. For the first time, they have succeeded in generating and simultaneously a more

• Researchers devise cheaper, faster way to continuously produce amines
  

  Researchers at North Carolina State University have developed a faster, less expensive technique for producing hindered amines – a class of chemicals used as building blocks in products ranging from pharmaceuticals and agrochemicals to detergents and organic light emitting diodes. “Hindered amines a more

• Alternative process for converting white phosphorus promises more sustainability in the chemical industry
  

  Chemists at the Technische Universität Dresden have developed a new, more sustainable process for synthesizing numerous important everyday chemicals from white phosphorus. The new process has the potential to establish innovative, more resource-efficient processes in the chemical industry. The groun more

Videos Synthesis

Microwave Peptide Synthesis – Pure Peptides in a Few Hours

CEM Corporation is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue microwave peptide synthesizer. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of t more

Narrow PSD Spherical Particles in Micron Range by Drying / Core-Shell Coating / Calcination in One Step

From nano to micro: drying, coating and calcining in just one process step with synthesis reactors from Glatt. Produce and coat powder materials with new, previously unattained properties in the pulsating hot gas stream of the patented Glatt powder synthesis. Thanks to the particularly homogeneous t more

Cyrene™ Bio-Renewable Dipolar Aprotic Solvent

Due to their health hazards, NMP and DMF are now included in the REACH restriction list. If you had regularly used these solvents, you’ll be glad to know we offer a perfect alternative: Cyrene™. Our “green” dipolar aprotic bicyclic chiral solvent is harmless for users, safer for the environment, and more

White papers Synthesis

• Chemists Need Tools that Allow them to Better Profile Organo-Metallic Reactions
  

  Advantages of automated sampling in a case study testing the practice of EasySampler for reaction profiling of an organo-metallic reaction more

• Innovative Techniques to Synthesize Breakthrough Molecules
  

  Four case studies highlight how top pharmaceutical companies are implementing new synthesis techniques and the impact on the chemical synthesis lab more

• In Situ Monitoring of Chemical Reactions – A Molecular Video
  

  While the technique has gained increased popularity in recent times, the principal of in situ reaction monitoring dates back to 1961 when Farenfort introduced a new method of measurement that today is called Attenuated Total Reflectance (ATR). The co more

Publications Synthesis

• Silver(I)-catalyzed sequential hydroamination and Prins type cyclization for the synthesis of fused benzo--sultams

  An intramolecular annulation strategy has been developed for the synthesis of tetrahydrobenzo[e]pyrano[4,3-c][1,2]thiazine derivatives by means of coupling of aldehydes with 2-(4-hydroxybut-1-yn-1-yl)-N-arylsulfonamides using a catalytic amount of silver hexafluoroantimonate in toluene at 80 °C. Thi more

• An efficient iodine pentoxide-triggered iodocarbocyclizations for the synthesis of iodooxindoles in water

  An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was us more

• Copper-Catalyzed Cyclization of 2-Cyanobenzaldehydes and 2-Isocyanoacetates: an Efficient Strategy for the Synthesis of Substituted 1-Aminoisoquinolines

  A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinoline. The reaction proceeds smoothly under mild conditions with high efficiency, and might provid more

q&more articles Synthesis

• Modular biofactories at the cellular level
  

  Despite his love for complex molecular architectures, this „dyed-in-the-wool“ bio-organic chemist has never embraced the conventional segregation of synthetic polymers and bio­logical macromolecules. All molecules are composed of atoms, after all. Why make an artificial distinction? Why not simply combine these domains together? more

• With Light in the Fight against Malaria
  

  Malaria represents a global threat to health, which is difficult to keep under control. Amongst more than 200 million sufferers, over 500,000 die each year of the disease, with the risk of a fatal outcome being particularly high in children [1]. more

• Customized ligands pave the way for new reaction pathways
  

  For the first time, an efficient catalyst for palladium-catalyzed C–C bonding between aryl chlorides and alkyl lithium compounds has been found. This reaction enables simpler synthesis routes for important products, such as pharmaceuticals, while avoiding much salt waste. more

Authors Synthesis

• Prof. Dr. Ulrich S. Schubert
  

  Ulrich S. Schubert, born in 1969, is Chair (W3) for Organic and Macromolecular Chemistry at Friedrich Schiller University Jena, Germany. He studied chemistry at the Universities of Frankfurt and Bayreuth and subsequently received his PhD from the Universities of Bayreuth and South Florida, Tampa, US more

• Prof. Dr. Peter Seeberger
  

  born 1966, studied chemistry at the University of Erlangen-Nuremberg, and received his doctorate in biochemistry from the University of Colorado. After holding a post-doctorate position at the Sloan-Kettering Institute for Cancer Research in New York City, he was Assistant Professor and Firmenich As more

• Mathies V. Evers
  

  Mathies Evers, born in 1989, studied chemistry at the Ruhr University Bochum, where he researched the synthesis of atom-precise molecular clusters. After his master's degree he started his doctoral thesis at the Chair of Analytical Chemistry II of Professor Dr. Kristina Tschulik and is supported by more