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SERS for Label-Free Biosensing

Life Science, Raman, SERS

Cicely Rathmell, M.Sc.

Figure 1: Modular fiber optic Raman spectroscopy system for SERS detection

Figure 2: In a hybrid SERS probe for ultrasensitive biosensing, popcorn-shaped gold nanoparticles (spiked balls) result in electromagnetic enhancement of the SERS signal, while conjugated graphene oxide (grey mesh) provides chemical enhancement

Figure 3: SERS-based detection of a segment of the HIV-1 gag-gene using popcorn-shaped gold nanoparticles conjugated with graphene oxide (black) and with the gold nanoparticle alone (red)

Figure 4: SERS-based detection of MRSA using popcorn-shaped gold nanoparticles conjugated with graphene oxide (purple), with the gold nanoparticle alone (blue) and with graphene oxide alone (red)

Surface enhanced Raman sensing (SERS) has expanded the applications of Raman spectroscopy to include trace analysis of materials such as explosives residues, evidence at crime scenes, chemical warfare agents and pesticides. As a label-free technique, SERS is also well suited to biosensing, from blood glucose to diagnosis of diseases like cancer, Alzheimer’s and Parkinson’s. A new variant of SERS developed by a group at Jackson State University in Mississippi, U.S., uses a hybrid probe composed of graphene oxide attached to a popcorn-shaped gold nanoparticle to achieve ultrasensitive sensing of HIV and MRSA DNA characteristics.

Facts, background information, dossiers
  • HIV diagnostics
  • Methicillin-resista…
  • cancer diagnostics
  • clinical diagnostics
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