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Cefazolin



Cefazolin
Systematic (IUPAC) name
3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-
8-oxo-7-([2-(tetrazol-1-yl)acetyl]amino)- 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate
Identifiers
CAS number 25953-19-9
ATC code J01DB04
PubChem 33255
Chemical data
Formula C14H13N8O4S3 
Mol. mass 454.51 g/mol
Pharmacokinetic data
Bioavailability NA
Metabolism  ?
Half life 1.8 hours (given IV)
2 hours (given IM)
Excretion Renal, unchanged
Therapeutic considerations
Pregnancy cat.

B1(AU) B(US)

Legal status

Prescription only

Routes Intravenous, intramuscular

Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.

Additional recommended knowledge

The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).

Indications

Cefazolin is mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. These organisms are common on normal human skin. Resistance to cefazolin is seen in several species of bacteria.

Side effects

Side effects from cefazolin are not common. Possible side effects include:

  • diarrhea
  • stomach pain
  • upset stomach
  • vomiting

Cefazolin is marketed under the following brand names: Ancef®, Cefacidal®, Cefamezin®, Cefrina®, Elzogram®, Faxilen®, Gramaxin®, Kefazol®, Kefol®, Kefzol®, Kefzolan®, Kezolin®, Novaporin®, and Zolicef®

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefazolin". A list of authors is available in Wikipedia.
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