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Systematic (IUPAC) name
carboxylic acid
CAS number 82619-04-3
ATC code J01DD13
PubChem 6335986
Chemical data
Formula C15H17N5O6S2 
Mol. mass 427.458 g/mol
Pharmacokinetic data
Bioavailability 50%
Protein binding 21% to 29%
Metabolism Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Half life 2 hours
Excretion Renal, unchanged
Therapeutic considerations
Pregnancy cat.

B1(AU) B(US)

Legal status


Routes Oral

Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin®) is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment. Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef® for veterinary use. The dose range in dogs is 5-10 mg/kg body weight, administered orally, once a day. Outside the US, Cefpodoxime proxetil is marketed as Banan®.


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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefpodoxime". A list of authors is available in Wikipedia.
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