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Cefamandole



Cefamandole
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-
3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 34444-01-4
42540-40-9 (nafate)
ATC code J01DC03
PubChem 456255
Chemical data
Formula C18H18N6O5S2 
Mol. mass 462.505 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 75%
Metabolism  ?
Half life 48 minutes
Excretion Mostly renal, as unchanged drug
Therapeutic considerations
Pregnancy cat.

B1(AU)

Legal status

POM(UK) Discontinued (US)

Routes Intramuscular, intravenous

Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.

Additional recommended knowledge

Cefamandole is no longer available in the United States.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefamandole". A list of authors is available in Wikipedia.
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