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L-type calcium channel



The L-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

L-type calcium channel blockers are used as antiarrhythmics or antihypertensives, depending on whether the drugs has higher affinity to the heart (like verapamil) or to the vessels (nifedipine).

L-type channels are selectively blocked by dihydropyridines.

See also

  • Cardiac_action_potential#Major_currents

In skeletal muscle, there is a very high concentration of DHP receptors, representing L-type calcium channels, situated in the T-tubules. Muscle depolarization results in large gating currents, but anomolously low calcium flux, which is now explained by the very slow activation of the ionic currents. For this reason, little or no Ca2þ passes across the T-tubule membrane during a single action potential.

Genes

  • CACNA1C, CACNA1D, CACNA1S, CACNA1F

See also

  • CACNA1C
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channelVoltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channelNavα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel
K+: Potassium channelVoltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9)
Cl-: Chloride channelCystic fibrosis transmembrane conductance regulator
PorinAquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1)
Cations: TRPTRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6)
Other/generalVoltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "L-type_calcium_channel". A list of authors is available in Wikipedia.
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