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Mestranol



Mestranol
Systematic (IUPAC) name
(8S,9S,13S,14S,17S)-17-ethynyl-3-methoxy-
13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-
cyclopenta[a]phenanthren-17-ol
Identifiers
CAS number 72-33-3
ATC code  ?
PubChem 6291
Chemical data
Formula C21H26O2 
Mol. mass 310.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.

Additional recommended knowledge

It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 µg of mestranol is pharmacokinetically bioequivalent to 35 µg of ethinylestradiol).[1]

References

  1. ^ Faigle, Johann W.; Schenkel, Lotte (1998). "Pharmacokinetics of estrogens and progestogens", in in Fraser, Ian S. (ed.): Estrogens and Progestogens in Clinical Practice. London: Churchill Livingstone, pp. 273-294. ISBN 0-443-04706-5. 


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mestranol". A list of authors is available in Wikipedia.
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