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Nafarelin



Nafarelin
Systematic (IUPAC) name
 ?
Identifiers
CAS number 76932-56-4
ATC code H01CA02
PubChem  ?
DrugBank APRD01129
Chemical data
Formula C66H83N17O13 
Mol. mass 1321.6344 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2.6 to 4 hours
Excretion renal
Therapeutic considerations
Pregnancy cat.

X

Legal status

℞-only

Routes Nasal spray

Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF.

Additional recommended knowledge

It is normally delivered via a nasal spray.

Nafarelin acetate is marketed by Searle under the brand name Synarel.

Side effects

Side effects of nafarelin are mostly related to the low estrogen state. Side effects include hot flashes, vaginal dryness, headaches, mood changes, and decreased interest in sex. Some patients may experience acne, muscle pain, reduced breast size, and irritation of the tissue inside the nose. These side effects should disappear after stopping the medication.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nafarelin". A list of authors is available in Wikipedia.
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