New System for Microwave-Assisted Peptide Synthesis
The application of microwave energy has proved to be a major enabling tool for many chemical applications requiring energy input. A new technique for microwave-assisted, solid-phase peptide synthesis has been developed that allows for coupling times as low as two minutes. A single-mode cavity is used to allow for a high microwave power density and a uniform field distribution. A vessel is placed inside of the cavity to allow for filtration of the solution and easy addition of reagents. Also, enhanced cleavage of the final peptide product from the resin takes place in the microwave cavity. The technique uses microwave irradiation and cooling simultaneously to keep the overall bulk temperature of the solution low, while allowing for maximum microwave energy input. This method allows for simple automation that will also be discussed.
Microwave energy allows for higher resin substitution and less excess reagents to be used, increasing scale-up potential when compared to traditional methods. Aggregation is lessened by microwave energy allowing for the possibility of longer peptide sequences. The use of a universal method for microwave-assisted, solid-phase peptide synthesis will be explored. Specific examples of the effects of the microwave energy on coupling times, yields, racemization, sequence length, and scale up will be presented and discussed.
CEM Corporation announced the formation of a new subsidiary headquartered in Tokyo with an additional office in Osaka, Japan. CEM Japan will be responsible for all sales, marketing, technical support and service of the Company’s entire line of laboratory instrumentation in Japan and selecte ... more
CEM announced that its fourth US patent covering microwave-assisted peptide synthesis (US7,582,728) was issued on September 1, 2009. The patent contains broad claims regarding the process of using microwave energy to accelerate two key steps in performing almost all solid phase peptide synt ... more
CEM Corporation has won a 2009 Presidential Green Chemistry Challenge Award in the Greener Reaction Conditions category for its Sprint(TM) Rapid Protein Analyzer. The company accepted the award during a ceremony at the Carnegie Institute for Science (CIS) inWashington, DC.
The award, prese ... more
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CEM is the leading provider of microwave solutions for the laboratory, industrial and scientific marketplace. Since creating this market 20 years ago, we have sold almost 20,000 systems. Despite this obvious success, we believe microwave chemistry is still an emerging technology and present ... more
CEM Corporati on is a private company based in Matt hews, North Carolina and the leading global provider of microwave laboratory instrumentati on for bioscience, chemical synthesis, analytical, and compositional testing applications, which in many instances have helped reduce or eliminate t ... more