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Systematic (IUPAC) name
CAS number 125-84-8
ATC code L02BG01
PubChem 2145
DrugBank APRD00592
Chemical data
Formula C13H16N2O2 
Mol. mass 232.278 g/mol
Pharmacokinetic data
Bioavailability >95%
Metabolism Hepatic
Half life 12.5 ± 1.6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

D: (USA)

Legal status
Routes Oral

Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.

Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.

It is still used to suppress corticosteroid production in Cushing's Syndrome.

See also

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aminoglutethimide". A list of authors is available in Wikipedia.
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