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Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.
Additional recommended knowledge
Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.
It is still used to suppress corticosteroid production in Cushing's Syndrome.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aminoglutethimide". A list of authors is available in Wikipedia.|