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Ifosfamide



Ifosfamide
Systematic (IUPAC) name
3-(2-chloroethyl)-2
-[(2-chloroethyl)amino]tetrahydro
-2H-1,3,2-oxazaphosphorine 2-oxide
Identifiers
CAS number 3778-73-2
ATC code L01AA06
PubChem 3690
DrugBank APRD00007
Chemical data
Formula C7H15Cl2N2O2P 
Mol. mass 261.1
Pharmacokinetic data
Bioavailability 100%
Metabolism Hepatic
Half life 60-80% in 72 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status

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Routes intravenously

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:

  • Testicular cancer
  • Breast cancer
  • Lymphoma (Non-Hodgkin)
  • Soft tissue sarcoma
  • Osteogenic sarcoma
  • Lung cancer
  • Cervical cancer
  • Ovarian cancer
  • Bone cancer

Additional recommended knowledge

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ifosfamide". A list of authors is available in Wikipedia.
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