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Verteporfin



Verteporfin
Systematic (IUPAC) name
 ?
Identifiers
CAS number 129497-78-5
ATC code L01XD02
PubChem 5362420
DrugBank APRD01290
Chemical data
Formula C41H42N4O8 
Mol. mass 718.794 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Intravenous

Verteporfin, otherwise known as benzoporphyrin derivative (trade name Visudyne®), is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.

Additional recommended knowledge

Administration

Verteporfin is given intravenously, within 15 minutes before laser treatment.

Side effects

Most commonly, blurred vision. Also, photosensitivity; it is advised to avoid exposure to sunlight and unscreened lighting until 48 hours after the injection of verteporfin.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Verteporfin". A list of authors is available in Wikipedia.
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