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Systematic (IUPAC) name
CAS number 154-93-8
ATC code L01AD01
PubChem 2578
DrugBank APRD00006
Chemical data
Formula C5H9Cl2N3O2 
Mol. mass 214.049 g/mol
Pharmacokinetic data
Bioavailability 5 to 28% (oral)
Protein binding 80%
Metabolism Hepatic (CYP1A2-mediated)
Half life 15 to 30 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

Prescription only

Routes Intravenous, wafer for implant

Carmustine or BCNU is a mustard gas-related β-chloro-nitrosourea compound used as an alkylating agent in chemotherapy. It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin). Carmustine for injection is marketed under the name BiCNU by Bristol-Myers Squibb.

Bone marrow may take 6 weeks to recover function following treatment with carmustine. Weekly monitoring of platelet and white blood cell counts are recommended as a basis for patient-specific adjustments to dosage regimens. Bone marrow and pulmonary toxicities are a function of lifetime cumulative dose.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Carmustine". A list of authors is available in Wikipedia.
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