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Systematic (IUPAC) name
N,N ' N '-triethylenethiophosphoramide
CAS number 52-24-4
ATC code L01AC01
PubChem 5453
Chemical data
Formula C6H12N3PS 
Mol. mass 189.219 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (CYP2B6, CYP2C11)
Half life 2.4 hours
15-18 hours (metabolites)
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status

POM(UK) -only(US)

Routes IV, intracavitary, intravesical

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.


  • Sykes M et al. (1953). "Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity". Cancer 6: 142-48.
  • Maanen MJ, Smeets CJ, Beijnen JH (2000). "Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA)". Cancer Treat Rev 26 (4): 257-68. PMID 10913381.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ThioTEPA". A list of authors is available in Wikipedia.
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