15-Jan-2013 - RSC Publishing

Novel SERS substrate allows fast cancer cell imaging

Fluorescence imaging is typically used to study biomolecules with high sensitivity and resolution, but many biological molecules are fluorescent themselves, limiting the potential of this technique. Surface enhanced Raman spectroscopy (SERS) is capable of high sensitivity but is not inhibited by the problems of autofluorescence. Folate receptors (FRs) are known to be overexpressed in many cancer cells.

Scientists in China have made graphene oxide–silver nanoparticle composites functionalised with folic acid (which can bind to the FRs). These were introduced into cancer cells and the localisation was then visualised using SERS mapping (the graphene oxide signal is very strong and can be used as an identifier of the composite). Only the FR-positive cells show a signal on the SERS map. The method is very fast with an integration time of 0.06s per pixel.

Facts, background information, dossiers
  • surface-enhanced Ra…
More about RSC Publishing
More about SCNU
  • News

    Economical PEF Production

    One possible replacement for drink containers made from PET is polyethylene furandicarboxylate (PEF), made from renewable resources. However, the production of the raw material for PEF from biomass is still rather inefficient. A new titanium-based photocatalyst could be about to change this ... more

    Ammonia by Phosphorus Catalysis

    More than 100 years after the introduction of the Haber–Bosch process, scientists continue to search for alternative ammonia production routes that are less energy demanding. Chinese scientists have now discovered that black phosphorus is an excellent catalyst for the electroreduction of ni ... more