Chemists and engineers are constrained at the bench when exploring a wide range of experimental conditions. Researchers are applying technology to expand the research and development of new synthetic pathways and optimized process conditions. This paper presents four case studies highlighting how leading Pharmaceutical companies are improving the performance of the chemical synthesis lab. Examples include:
- Identifying conditions for a successful triflation reaction
- Avoiding impurity formation during a Guanidine reaction
- Central composite Design of Experiment (DoE)
- Inline reaction rate meter tracking a Lithium Borohydride reduction
