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Proglumetacin



Proglumetacin
Systematic (IUPAC) name
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-
methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]
propyl 4-(benzoylamino)-5-(dipropylamino)-
5-oxopentanoate
Identifiers
CAS number 57132-53-3
59209-40-4 (maleate)
ATC code M01AB14
PubChem 4921
Chemical data
Formula C46H58ClN5O8 
Mol. mass 844.43442 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic. Undergoes enterohepatic recirculation
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.


v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products, non-steroids		Butylpyrazolidines (Phenylbutazone, Mofebutazone, Oxyphenbutazone, Clofezone, Kebuzone)

Acetic acid derivatives and related substances (Indometacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Alclofenac, Bumadizone, Etodolac, Lonazolac, Fentiazac, Acemetacin, Difenpiramide, Oxametacin, Proglumetacin, Ketorolac, Aceclofenac, Bufexamac)

Oxicams (Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam)

Propionic acid derivatives (Ibuprofen, Naproxen, Ketoprofen, Fenoprofen, Fenbufen, Benoxaprofen, Suprofen, Pirprofen, Flurbiprofen, Indoprofen, Tiaprofenic acid, Oxaprozin, Ibuproxam, Dexibuprofen, Flunoxaprofen, Alminoprofen, Dexketoprofen)

Fenamates (Mefenamic acid, Tolfenamic acid, Flufenamic acid, Meclofenamic acid)

Coxibs (Celecoxib, Rofecoxib, Valdecoxib, Parecoxib, Etoricoxib, Lumiracoxib)

other anti-inflammatory and antirheumatic agents, non-steroids (Nabumetone, Niflumic acid, Azapropazone, Glucosamine, Benzydamine, Glucosaminoglycan polysulfate, Proquazone, Orgotein, Nimesulide, Feprazone, Diacerein, Morniflumate, Tenidap, Oxaceprol, Chondroitin sulfate)
Specific antirheumatic agentsQuinolines (Oxycinchophen) - Gold preparations (Sodium aurothiomalate, Sodium aurothiosulfate, Auranofin, Aurothioglucose, Aurotioprol) - Penicillamine/Bucillamine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Proglumetacin". A list of authors is available in Wikipedia.
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