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Apraclonidine



Apraclonidine
Systematic (IUPAC) name
2,6-dichloro-N- (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Identifiers
CAS number 66711-21-5
ATC code S01EA03
PubChem 2216
DrugBank APRD00012
Chemical data
Formula C9H10Cl2N4 
Mol. mass 245.108 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 98.7%
Metabolism  ?
Half life 8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Ophthalmic solution

Apraclonidine (INN), also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an α2-adrenergic agonist.

Additional recommended knowledge

Apraclonidine is administered at a concentration of 1% for the prevention and treatment of postsurgical intraocular pressure elevation and 0.5% for short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional redirection of intraocular pressure. One drop is usually added one hour prior to laser eye surgery and another drop is given after the procedure is complete.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Apraclonidine". A list of authors is available in Wikipedia.
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