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Brimonidine



Brimonidine
Systematic (IUPAC) name
5-bromo-N- (4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine
Identifiers
CAS number 59803-98-4
ATC code S01EA05
PubChem 2435
DrugBank APRD00034
Chemical data
Formula C11H10BrN5 
Mol. mass 292.135 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism liver primarily
Half life 3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B

Legal status

unknown

Routes Ocular, 1 gtt

Brimonidine (bri-MOE-ni-deen ) is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis.

Additional recommended knowledge

Brimonidine is an alpha2 receptor agonist.

Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the production of AC. This reduces cAMP and hence Aqueous Humour production by the ciliary body.

Side effects

  • Conjunctivitis
  • Conjunctival hyperemia
  • Ocular pruritus
  • Ocular burning
  • Conjunctival follicles
  • Hypertension
  • Dry mouth
  • Visual changes
  • Somnolence


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Brimonidine". A list of authors is available in Wikipedia.
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