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Systematic (IUPAC) name
CAS number 3575-80-2
ATC code N05AD03
PubChem 15387
Chemical data
Formula C16H22FNO 
Mol. mass 263.35 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (inhibits CYP2D6[1])
Half life 3–4 hours (oral)
6 hours (IM)
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Oral, intramuscular injection

Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.


  • Appearance: White, crystalline odorless powder
  • Solubility: Freely soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
  • Melting Point: 205-210C
  • pH (1% in water): 4.5-6.5
  • Stability: 48 months

It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).


  1. ^ Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). "Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine". Pharmacopsychiatry 36 (1): 3–6. doi:10.1055/s-2003-38084. PMID 12649767.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Melperone". A list of authors is available in Wikipedia.
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