My watch list
my.chemeurope.com  
Login  

Loxapine



Loxapine
Systematic (IUPAC) name
2-Chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
Identifiers
CAS number 1977-10-2
ATC code N05AH01
PubChem 3964
DrugBank APRD00574
Chemical data
Formula C18H18ClN3O 
Mol. mass 327.808 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life Oral-4 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and as a dibenzazepine derivative, it is structurally related to clozapine (which belongs to the chemically closely akin class of dibenzodiazepines). Several researchers have argued that Loxapine may behave as an atypical antipsychotic (PMID 10340686).

Additional recommended knowledge

Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant (PMID 1860915).

Side effects

Further information: Typical antipsychotic

The most significant side-effects of loxapine are excessive salivation and indifference to surroundings. Loxapine, if administered to normal persons causes emotional quietening and insensitivity. In persons with psychosis, it may control aggressive behaviour and restlessness, and reduce the severity of hallucinations and delusions. Other Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor, gynecomastia and sedation.

Dosage

The typical starting dosage is 10mg twice daily; usual dose range 30-50mg twice daily; maximum recommended dosage is 250mg per day.



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Loxapine". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE