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Systematic (IUPAC) name
CAS number 14028-44-5
ATC code N06AA17
PubChem 2170
DrugBank APRD00142
Chemical data
Formula C17H16ClN3O 
Mol. mass 313.781
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (cytochrome P450 system)
Half life 8-10 hours (30 hours for major metabolites)
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status


Routes Oral

Amoxapine (brand-names Asendin®, Asendis®, Defanyl®, Demolox®, Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.

Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.

See also


  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amoxapine". A list of authors is available in Wikipedia.
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