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Protriptyline



Protriptyline
Systematic (IUPAC) name
N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Identifiers
CAS number 438-60-8
ATC code N06AA11
PubChem 4976
Chemical data
Formula C19H21N 
Mol. mass 263.377 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 54-92 hours
Excretion Renal, in urine
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

Schedule VI (US)

Routes Oral

Protriptyline (Vivactil®) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the tricyclics, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect.[citation needed] (The other TCAs tend to be sedating and therefore are often taken in the evening.)

Additional recommended knowledge

Tricyclics including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Protriptyline". A list of authors is available in Wikipedia.
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