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Pargyline is a monoamine oxidase B (MAO-B) inhibitor. It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.
Additional recommended knowledge
- ^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006
|Psychoanaleptics: antidepressants (N06A)|
|MAOIs||Iproclozide • Iproniazid • Isocarboxazid • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine |
RIMAs: Brofaromine • Beta-carbolines (Harmaline) • Moclobemide
||SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine)
• TCAs/Tetras (Clomipramine, Nefazodone, Trazodone)
|N RI / A RI
||Atomoxetine • Maprotiline • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine, Maprotiline)
||Vanoxerine • Phenmetrazine • TCAs (Amineptine)
||Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine
||Brasofensine • Tesofensine • Nomifensine
|AAs||Tetras (Mianserin, Mirtazapine)|